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Index > Protein center > GLI1(Gene name) > Human
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  • GLI1 (Gene name),
  • Zinc finger protein GLI1 (Protein name ),  GLI1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GLI1(GLI);
    Protein name:
    Zinc finger protein GLI1;
    Alternative:
    Oncogene GLI;Glioma-associated oncogene;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with KIF7 (By similarity). Interacts with ZIC1; the interaction enhances transcription activation.
    Function:
    Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
    Subcellular Location:
    Cytoplasm Nucleus Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
    Protein Attributes:
    Sequence length:
    1106
    Sequence:
    50:
    MFNSMTPPPI | SSYGEPCCLR | PLPSQGAPSV | GTEGLSGPPF | CHQANLMSGP | 
    100:
    HSYGPARETN | SCTEGPLFSS | PRSAVKLTKK | RALSISPLSD | ASLDLQTVIR | 
    150:
    TSPSSLVAFI | NSRCTSPGGS | YGHLSIGTMS | PSLGFPAQMN | HQKGPSPSFG | 
    200:
    VQPCGPHDSA | RGGMIPHPQS | RGPFPTCQLK | SELDMLVGKC | REEPLEGDMS | 
    250:
    SPNSTGIQDP | LLGMLDGRED | LEREEKREPE | SVYETDCRWD | GCSQEFDSQE | 
    300:
    QLVHHINSEH | IHGERKEFVC | HWGGCSRELR | PFKAQYMLVV | HMRRHTGEKP | 
    350:
    HKCTFEGCRK | SYSRLENLKT | HLRSHTGEKP | YMCEHEGCSK | AFSNASDRAK | 
    400:
    HQNRTHSNEK | PYVCKLPGCT | KRYTDPSSLR | KHVKTVHGPD | AHVTKRHRGD | 
    450:
    GPLPRAPSIS | TVEPKREREG | GPIREESRLT | VPEGAMKPQP | SPGAQSSCSS | 
    500:
    DHSPAGSAAN | TDSGVEMTGN | AGGSTEDLSS | LDEGPCIAGT | GLSTLRRLEN | 
    550:
    LRLDQLHQLR | PIGTRGLKLP | SLSHTGTTVS | RRVGPPVSLE | RRSSSSSSIS | 
    600:
    SAYTVSRRSS | LASPFPPGSP | PENGASSLPG | LMPAQHYLLR | ARYASARGGG | 
    650:
    TSPTAASSLD | RIGGLPMPPW | RSRAEYPGYN | PNAGVTRRAS | DPAQAADRPA | 
    700:
    PARVQRFKSL | GCVHTPPTVA | GGGQNFDPYL | PTSVYSPQPP | SITENAAMDA | 
    750:
    RGLQEEPEVG | TSMVGSGLNP | YMDFPPTDTL | GYGGPEGAAA | EPYGARGPGS | 
    800:
    LPLGPGPPTN | YGPNPCPQQA | SYPDPTQETW | GEFPSHSGLY | PGPKALGGTY | 
    850:
    SQCPRLEHYG | QVQVKPEQGC | PVGSDSTGLA | PCLNAHPSEG | PPHPQPLFSH | 
    900:
    YPQPSPPQYL | QSGPYTQPPP | DYLPSEPRPC | LDFDSPTHST | GQLKAQLVCN | 
    950:
    YVQSQQELLW | EGGGREDAPA | QEPSYQSPKF | LGGSQVSPSR | AKAPVNTYGP | 
    1000:
    GFGPNLPNHK | SGSYPTPSPC | HENFVVGANR | ASHRAAAPPR | LLPPLPTCYG | 
    1050:
    PLKVGGTNPS | CGHPEVGRLG | GGPALYPPPE | GQVCNPLDSL | DLDNTQLDFV | 
    1100:
    AILDEPQGLS | PPPSHDQRGS | SGHTPPPSGP | PNMAVGNMSV | LLRSLPGETE | 
    1106:
    FLNSSA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    SMR:
    MIM:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Zinc finger protein GLI1
    Cat.:
    E15198m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Zinc finger protein GLI1
    Cat.:
    E15198h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Zinc finger protein GLI1
    Cat.:
    E15198c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc finger protein GLI1
    Cat.:
    U15198m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc finger protein GLI1
    Cat.:
    U15198c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc finger protein GLI1
    Cat.:
    U15198h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Zinc finger protein GLI1
    Polyclonal Antibody for Human Zinc finger protein GLI1
    Cat.:
    P15198Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Zinc finger protein GLI1
    Cat.:
    P15198Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Zinc finger protein GLI1
    Monoclonal Antibody for Human Zinc finger protein GLI1
    Monoclonal Antibody for Human Zinc finger protein GLI1
    Protein for Human Zinc finger protein GLI1
    Protein for Human Zinc finger protein GLI1
    Protein for Human Zinc finger protein GLI1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The GLI gene is a member of the Kruppel family of zinc finger proteins."
      Kinzler K.W. , Ruppert J.M. , Bigner S.H. , Vogelstein B.
      Nature332:371-374(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Polymorphic variants of the human oncogene GLI1 function similarly."
      Yoon J.W. , Kent P. , Clark A. , Patterson J. , Villavicencio E. , Iannaccone P. , Walterhouse D.
      Submitted (2000-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-933 AND GLN-1100
    3. 3.
      "A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."
      Lo H.W. , Zhu H. , Cao X. , Aldrich A. , Ali-Osman F.
      Cancer Res.69:6790-6798(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    6. 6.
      "Gli regulation by the opposing activities of fused and suppressor of fused."
      Murone M. , Luoh S.-L. , Stone D. , Li W. , Gurney A. , Armanini M. , Grey C. , Rosenthal A. , de Sauvage F.J.
      Nat. Cell Biol.2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH STK36 AND SUFU
    7. 7.
      "Physical and functional interactions between Zic and Gli proteins."
      Koyabu Y. , Nakata K. , Mizugishi K. , Aruga J. , Mikoshiba K.
      J. Biol. Chem.276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZIC1;SUBCELLULAR LOCATION
    8. 8.
      "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."
      Maloverjan A. , Piirsoo M. , Michelson P. , Kogerman P. , Osterlund T.
      Exp. Cell Res.316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-518
    10. 10.
      "Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers."
      Pavletich N.P. , Pabo C.O.
      Science261:1701-1707(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 234-388
    11. 11.
      "Identification of polymorphic variants of the GLI1 oncogene."
      Wang X.Q. , Chan N. , Rothnagel J.A.
      J. Invest. Dermatol.115:328-329(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-884; ASP-933 AND GLN-1100
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-210; ILE-514 AND GLN-817
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